1802175-06-9 | CPI-360
CPI-360 is a drug that inhibits the activity of histone methyltransferases. It is used to treat cancer, as well as other diseases caused by abnormal changes in gene expression. CPI-360 has been shown to inhibit the catalytic subunit of the methyltransferase. In addition to preventing the methylation of histones, it also inhibits transcriptional regulation and nucleosome assembly. An advantage of this drug is that it does not affect normal cellular methylation processes.
1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-;
N-[(1,2-Dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indole-3-carboxamide;
CAS 1802175-06-9|CPI-360
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1802175-06-9 |
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C25H31N3O4 |
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437.53 |
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1.26±0.1 g/cm3(Predicted) |
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712.2±60.0 degree (Predicted) |
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11.01±0.10(Predicted) |
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DMF: 10 mg/mL; DMSO: 25 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH7.2) (1:7): 0.12 mg/mL |
P 1802175-06-9|CPI-360
Package:0.1g,1g,5g,25g,100g,500g,1kg
of CAS 1802175-06-9|CPI-360
[HTML] An alternative approach to ChIP-Seq normalization enables detection of genome-wide changes in histone H3 lysine 27 trimethylation upon EZH2 inhibition
B Egan, CC Yuan, ML Craske, P Labhart, GD Guler… - PloS one, 2016 - journals.plos.org
… Spike-in normalization does not significantly affect H3K9me3 signal in cells treated with
CPI-360 for 4 day and 8 days. (E) Scatter plots representing the correlation of all H3K27me3 and …
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